Enhancement of tumor growth by drugs with some common molecular actions
Identifieur interne : 003E49 ( Main/Exploration ); précédent : 003E48; suivant : 003E50Enhancement of tumor growth by drugs with some common molecular actions
Auteurs : Frank S. Labella [Canada] ; Lorne J. Brandes [Canada]Source :
- Molecular Carcinogenesis [ 0899-1987 ] ; 1996-06.
English descriptors
- KwdEn :
Abstract
A group of structurally related drugs representing diverse therapeutic classes share, among a number of pharmacological properties, enhancement of tumor growth in several rodent models of malignancy. One common action, the inhibition of histamine binding to and catalytic activity of cytochrome P450 monooxygenases, is highly correlated with potency to enhance tumor growth. Among members of this drug ensemble, the antiestrogen tamoxifen has been shown in controlled clinical studies to increase the incidence of uterine and gastrointestinal cancer and to accelerate the course of gastric cancer, and the tamoxifen analogue clomiphene has been linked to neuroblastoma and the tricyclic group of antidepressants to ovarian cancer. The determination of drug affinities for protein modulators of cell growth, proliferation, and transformation suggests a strategy for identifying at least some classes of chemicals that impart oncologic risks to humans. © 1996 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/(SICI)1098-2744(199606)16:2<68::AID-MC2>3.0.CO;2-J
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001525
- to stream Istex, to step Curation: 001525
- to stream Istex, to step Checkpoint: 001859
- to stream Main, to step Merge: 004539
- to stream Main, to step Curation: 003E49
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Enhancement of tumor growth by drugs with some common molecular actions</title><author><name sortKey="Labella, Frank S" sort="Labella, Frank S" uniqKey="Labella F" first="Frank S." last="Labella">Frank S. Labella</name></author><author><name sortKey="Brandes, Lorne J" sort="Brandes, Lorne J" uniqKey="Brandes L" first="Lorne J." last="Brandes">Lorne J. Brandes</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CEB7B29D3E7618FC4309449AEE97B1D139CD1A96</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1002/(SICI)1098-2744(199606)16:2<68::AID-MC2>3.0.CO;2-J</idno><idno type="url">https://api-v5.istex.fr/document/CEB7B29D3E7618FC4309449AEE97B1D139CD1A96/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001525</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001525</idno><idno type="wicri:Area/Istex/Curation">001525</idno><idno type="wicri:Area/Istex/Checkpoint">001859</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001859</idno><idno type="wicri:doubleKey">0899-1987:1996:Labella F:enhancement:of:tumor</idno><idno type="wicri:Area/Main/Merge">004539</idno><idno type="wicri:Area/Main/Curation">003E49</idno><idno type="wicri:Area/Main/Exploration">003E49</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Enhancement of tumor growth by drugs with some common molecular actions</title><author><name sortKey="Labella, Frank S" sort="Labella, Frank S" uniqKey="Labella F" first="Frank S." last="Labella">Frank S. Labella</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Pharmacology and Therapeutics and Medicine, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation><affiliation wicri:level="4"><country>Canada</country><wicri:regionArea>Department of Pharmacology and Therapeutics, University of Manitoba, Faculty of Medicine, 770 Bannatyne Avenue, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Brandes, Lorne J" sort="Brandes, Lorne J" uniqKey="Brandes L" first="Lorne J." last="Brandes">Lorne J. Brandes</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Pharmacology and Therapeutics and Medicine, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Manitoba Institute of Cell Biology, Winnipeg, Manitoba</wicri:regionArea><wicri:noRegion>Manitoba</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Molecular Carcinogenesis</title><title level="j" type="sub">Published in cooperation with the University of Texas M.D. Anderson Cancer Center</title><title level="j" type="abbrev">Mol. Carcinog.</title><idno type="ISSN">0899-1987</idno><idno type="eISSN">1098-2744</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1996-06">1996-06</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="68">68</biblScope><biblScope unit="page" to="76">76</biblScope></imprint><idno type="ISSN">0899-1987</idno></series><idno type="istex">CEB7B29D3E7618FC4309449AEE97B1D139CD1A96</idno><idno type="DOI">10.1002/(SICI)1098-2744(199606)16:2<68::AID-MC2>3.0.CO;2-J</idno><idno type="ArticleID">MC2</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0899-1987</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>animal models of cancer</term><term>antidepressants</term><term>antihistamines</term><term>cytochrome P450 monooxygenase</term><term>histamine</term><term>polyamines</term><term>tamoxifen</term><term>tumor promotion</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A group of structurally related drugs representing diverse therapeutic classes share, among a number of pharmacological properties, enhancement of tumor growth in several rodent models of malignancy. One common action, the inhibition of histamine binding to and catalytic activity of cytochrome P450 monooxygenases, is highly correlated with potency to enhance tumor growth. Among members of this drug ensemble, the antiestrogen tamoxifen has been shown in controlled clinical studies to increase the incidence of uterine and gastrointestinal cancer and to accelerate the course of gastric cancer, and the tamoxifen analogue clomiphene has been linked to neuroblastoma and the tricyclic group of antidepressants to ovarian cancer. The determination of drug affinities for protein modulators of cell growth, proliferation, and transformation suggests a strategy for identifying at least some classes of chemicals that impart oncologic risks to humans. © 1996 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Manitoba</li></region><settlement><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><country name="Canada"><region name="Manitoba"><name sortKey="Labella, Frank S" sort="Labella, Frank S" uniqKey="Labella F" first="Frank S." last="Labella">Frank S. Labella</name></region><name sortKey="Brandes, Lorne J" sort="Brandes, Lorne J" uniqKey="Brandes L" first="Lorne J." last="Brandes">Lorne J. Brandes</name><name sortKey="Brandes, Lorne J" sort="Brandes, Lorne J" uniqKey="Brandes L" first="Lorne J." last="Brandes">Lorne J. Brandes</name><name sortKey="Labella, Frank S" sort="Labella, Frank S" uniqKey="Labella F" first="Frank S." last="Labella">Frank S. Labella</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003E49 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003E49 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:CEB7B29D3E7618FC4309449AEE97B1D139CD1A96
|texte= Enhancement of tumor growth by drugs with some common molecular actions
}}
| This area was generated with Dilib version V0.6.29. |  |